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The U.S. Food and Drug Administration has approved the application of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to help you manage chronic obesity in older adults with a body mass index (BMI) of more than 27, provided that they also are afflicted by weight-related health problems such as Tupe2 diabestes, high-cholesterol and/or hypertension (high blood pressure levels).Contrave is a combination of two FDA-approved drugs, naltrexone and bupropion, in an extended-release formulation. Naltrexone is eligible to treat alcohol and opioid dependence. Bupropion is approved to treat depression and seasonal affective disorder in addition to being an aid to smoking cessation treatment.'Obesity is still a major public health concern,' said Jean-Marc Guettier, M.D., director with the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination which has a healthy lifestyle which includes a reduced-calorie dieting and exercise, Contrave provides another treatment selection for chronic weight reduction for people who are obese or are overweight and also have at least one weight-related health condition.'The drug's effectiveness was evaluated in multiple numerous studies that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated for one year. All patients received lifestyle modification that was comprised of a reduced- calorie diet and regular physical exercise. Results from a medical trial that enrolled patients without diabetes established that patients had a typical weight loss of four.1% instead of participants who were given placebos) after a 12- month period, while another study involving patients with diabetes type 2 symptoms had a normal weight loss of 2% over treatment with placebo at one year.

Using two separate drugs to shed pounds can be very effective there are combinations in front of the FDA now awaiting approval. When dealing with weight loss and the those who go through it you ought to err assisting caution and allow the FDA do its job and demand some investigation be done so the public knows the side effects and perils associated with the medications before we take them. Keep in mind that drug companies will be in business to generate money and that they would say everything to keep people on his or her medications.

Researchers found that participants investing in this drug for the year, lost excess weight within 4 weeks and have kept the weight off throughout the 56 weeks with the study. Contrave is really a combination from the drugs naltrexone and bupropion, which usually reflect a new trend of weight-loss drugs that are made up of multiple active ingredient, which might make them more potent and safer.

Combo-pilling is the newest fad or even better the newest to come under scrutiny and for that reason it is just more publicly known recently, comb-pilling for losing weight has been around since the eighties. The biggest reason that employing a combination of pills is becoming popular is the fact that at the time of right now there are no long term prescription diet pills that have been approved by the FDA apart from orlistat. The truly disturbing part is doctors are prescribing these combinations of medications and some of the combinations are already rejected or have yet to be authorized by the FDA.

Seizures can be a side effect with Contrave and really should not be taken in those with seizure disorders. The drug also can raise blood pressure and pulse rate, and shouldn't be used in people who have a history of heart attack or stroke in the previous six months. Blood pressure and pulse should also be measured before commencing the drug and throughout therapy with the drug.

The FDA also warned that Contrave can raise blood pressure levels and heartrate and must not be used in patients with uncontrolled high blood pressure levels, and also by anyone with heart-related and cerebrovascular (circulation system dysfunction impacting the mind) disease. Patients having a history of cardiac arrest or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes with a boxed warning to alert health care professionals and patients towards the increased probability of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events are actually reported in patients taking bupropion for stop smoking.

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